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Heterocyclic Schiff Bases; Study and Prospects as Anticonvulsants

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Some novel schiff bases of 3-aminomethyl pyridine and 2-amino pyridine have been synthesized through condensation reaction with substituted aryl aldehydes/ketones and/alicyclic ketones. These schiff bases were screened for anticonvulsant activity, neurotoxicity and antideprassant activity. The chemical structures of synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR spectroscopy, and elemental analysis. In the preliminary anticonvulsant screening, three convulsant test models were used: maximal electro shock (MES), subcutaneous pentylenetetrazole (sc.PTZ), subcutaneous strychnine (sc.STY) and neurotoxicity screen (rotorod method in mice). Protective index (PI) is considered an index of the margin of safety and tolerability between anticonvulsant doses and doses of various synthesized compounds exerting acute adverse effects. In Phase-II screening in mice ED50 and TD50 and PI were determined. Some selected compounds were subjected to oral MES screen in rats and were found effective against MES test.

Product Specifications
SKU :COC30944
AuthorShailendra Pandey and Radhey S. Srivastava
LanguageEnglish
BindingPaperback
Number of Pages212
Publishing Year1/18/2012
ISBN978-3847338208
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00