The most important process in life is excretion because the metabolic waste products are eliminated by this. The elimination of drugs from the body takes place either as the parent drug or as metabolites. Famotidine is a medicine which belongs to the group of histamine blockers. The body begins to eliminate the drug by hepatic metabolism, renal or both, after administration of the dose. Famotidine is a potent and long acting histamine H2-receptor antagonist widely used in the treatment and prevention of duodenal ulcer. The total body clearances of famotidine determined with the help of creatinine clearance. Therefore this research will be very helpfull in the field of pharmacy.