This study is about how donor policy, NGO policy and public policy work together in Ghana’s national strategic response to HIV and AIDS. It touches on two areas of public policy - development policy and health policy specifically relating to HIV/AIDS to determine congruity of public, donor and NGO policies. Based on a survey done in Accra, Ghana in summer 2010 and on documentary sources of data collection, the study captures areas of agreement and disagreement in the three policy streams and discusses their effects on policy implementation. In broader terms, it analyzes assistance for HIV/AIDS in the context of international development aid and how current economic realities make such assistance unsustainable in the long term. It concludes by elaborating a prescriptive model of HIV policy intervention in Ghana with proposed modifications of the current model. This book illuminates the field of HID/AIDS policy making in Ghana in a manner that students of public health and public policy as well as officials from public, private and donor agencies working in the area of public health will find insightful.