HIV and AIDS is very critical issue in all over the world, most of the less development and developing countries are directly affected. However, there are still remaining poverty and famine problem, the HIV and AIDS derived also huge health and social problem. Among all less develop countries, Nepal has also same problem. Here are different most at risk groups are directly involved in risk activities, the groups are IDUs, MSM/MSW, FSW, Client of Sex Worker, Housewives, Children and Blood or organ recipients. In Nepal, most of the people are infected from lack of knowledge about HIV and AIDS, however some people knowledge about it, they are infected from their careless with sexual relation of sex partners. Now it is not only health problem but it is a social problem for example when people are infected, the infected people are faced social and traditional values because the Nepalese people only think that it would only suffer from sexual activities but the reality is different.