Indigenous knowledge contributes to the prevention, care and management of HIV and AIDS in Sikhobokhobo ward of Nkayi district. The knowledge also stands as a pillar of resource for the support of orphans and women in their ward''s response to HIV and AIDS. Data was collected through participant observations, life- histories, in-depth interviews, and focus group discussions. The responses given yielded data on people''s perceptions and the specific indigenous knowledge used by women in the prevention, care support and management of the HIV and AIDS pandemic. The study, the first of its kind in the ward shows how indigenous knowledge has been used by women in the response to HIV and AIDS. It highlights the role indigenous knowledge plays in the prevention of infection through the use of herbs to reduce and prevent promiscuity among people in a relationship. It also highlights how mothers during breast-feeding they can help control the future sexual desire of their children. The research concludes by highlighting the important aspect of indigenous knowledge in Sikhobokhobo that needed to be documented and communicated to the wide community.