Infertility is defined as the inability to conceive after one year of regular intercourse without the use of contraception. In the African setting infertility is seen as a violation of socially accepted norms. Parenthood is also considered culturally mandatory making the event of childlessness unacceptable. It not only contributes to psychological distress and challenges marital interactions, it also plays a key role in the loss of social security, status and gender identity. Unexplained infertility is diagnosed when the routine investigation of semen analysis, tubal patency and assessment of ovulation show no abnormality and the couple have engaged in regular sexual intercourse. It is therefore a diagnosis of exclusion. The aim of this study was to evaluate the efficacy of homoeopathic similimum treatment in females pre-diagnosed with unexplained infertility using case studies. Cases were evaluated holistically using fertility and related fertility parameters. General and concomittant symptoms were included in each individual's holistic case. The male partner was also required to be free of structural and functional pathology.