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Homology Modeling of Dopamine Receptors and Docking Study


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Dopamine receptors (DRs) belong to the class A of G-protein coupled receptors (GPCRs) super family. The five subtypes of dopamine receptors (DRs) i.e. D1R, D2R, D3R, D4R and D5R have been characterized and classified in D1-like (D1R and D5R; stimulatory) and D2-like (D2R, D3R, and D4R; inhibitory) subfamilies based on their sequence similarities and physiological response. The DRs are involved in many physiological processes and thus, deregulation in their activity led to the various mental disorders. Therefore, the DRs are attractive targets for the development of new drug molecules for the treatment of various CNS disorders. This book describes the development and validation of 3D structure model for all DR isoforms. The 3D structure model of DRs may be used in docking study to identify crucial amino acid residues involved Drug-Receptor interactions. This is turn, will contribute in the designing of novel DR agonists and antagonists. This is also helpful to understand the mechanism of activation and inhibition of these receptors. Also, the docking models will be useful In Silico activity prediction of new compounds as well as in virtual screening to identify new lead molecules.

Product Specifications
SKU :COC30322
AuthorManish K. Gupta,Gagandip Singh and Ankit Kumar
Number of Pages80
Publishing Year10/28/2012
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00