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Human Beta Defensins analogs as therapeutic targets for infections

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Human Beta Defensins (hBDs) are a class of antimicrobial peptides (AMPs) that play an important role both in innate and adaptive immunity: they kill bacteria, viruses and fungi and exert chemotaxis against lymphocytes and monocytes. Thanks to their properties, hBDs represent a target to develop therapeutic molecules. Previously, Scudiero et al. synthesized the wild type hBD1, hBD3 and designed analogs selecting the sequences crucial for the activity. In the present study, we tested the possibility to find a new defensin analog with enhanced properties. The new peptide has the following features: shorter total sequence; presence of the C-terminus portion of hBD3; presence of inner portion of hBD1. We perform antibacterial and antiviral tests on E. coli, P. aeruginosa, E. faecalis and simplex virus type 1. In addition, we investigated two pharmacological properties of these peptides: the stability in human serum and the cytotoxic effects on human cells. Finally, in order to investigate whether defensins interact with human epithelial cells, we labeled peptides with NBD fluorochrome and performed confocal microscopy experiments.

Product Specifications
SKU :COC87262
AuthorErsilia Nigro,Aurora Daniele and Olga Scudiero
LanguageEnglish
BindingPaperback
Number of Pages72
Publishing Year2013-06-22T00:00:00.000
ISBN9783659417429
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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