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Human Fidgetin and Its Functions in Mitosis and Cell Migration


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Microtubule is an essential component of the cytoskeleton required for several important cellular processes such as cell division, cellular morphogenesis and migration. In cells, functions of microtubules are tightly regulated by additional microtubule-associated proteins called MAPs. Fidgetin is a microtubule-associated protein, which influences several microtubule based cellular processes by regulating microtubule dynamics. Fidgetin is a microtubule severing and depolymerizing enzyme and possibility by utilizing these properties it regulates mitosis and cellular migration. Both of these processes are extremely important during cell proliferation and tissue morphogenesis. Defects in these processes may lead to malignant transformation and developmental defects including neurodegenerative disease, as the formation of neuronal processe is in many ways a modified form of cell migration. Notably, Fidgetin mutation causes developmental and behavioral defects in mice. This study might lead ways to the molecular etiology of these diseases and develop effective therapeutic strategies for their treatment.

Product Specifications
SKU :COC36911
AuthorSuranjana Mukherjee and David Sharp
Number of Pages96
Publishing Year2012-01-10T00:00:00.000
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-02-08 00:00:00