In today’s dynamic world of work and play, the availability of information is ever expanding. No matter what the source or form it takes, people face daunting challenges in the retrieval, use, and comprehension of information. Furthermore, people’s psychological health and physical well-being can have a notable influence on their use of information systems. This book offers a review and analysis of dissertation research findings covering a twelve-year period of published scholarship. Using the principles of domain analysis as well as observational reflection on a variety of information environments, this study provides the first empirically grounded description of the psychological aspects of human-information interaction (HII), and the relationship theories underlying the human-information dyad (HID). It includes a summary of the research findings on people’s use of information from the first decade of the 21st century, and proposes a series of models for future observation and analysis of the phenomena that comprise people’s use of information.