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Human STAT1 deficiencies

 

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  • Product Description
 

The Signal Transducer and Activator of Transcription 1 (STAT1) is activated in response to interferons (IFNs) stimulations. In response to IFN-?, STAT1 homodimerizes to form the gamma activating factor (GAF). In response to IFN-?, STAT1 heterotrimerizes with STAT2 and ISGF3-? to form the interferon sequence gene factor 3 (ISGF3). This work clearly demonstrates the distinct roles of the IFN-?-induced-GAF complexes in anti-mycobacterial immunity and of IFN-? induced- ISGF3 complexes in the anti-viral immunity in humans at the cellular and clinical levels by different molecular mechanisms. It also highlights the fact that a phenotype depends of the mutation and not only of the affected gene; and moreover the importance of the homozygosis or heterozygosis state of the mutation in human genetic diseases.

Product Specifications
SKU :COC99437
AuthorAriane Chapgier
LanguageEnglish
BindingPaperback
Number of Pages136
Publishing Year2011-02-15T00:00:00.000
ISBN978-3844301687
Edition1 st
Book TypeGenetics (non-medical)
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-18 00:00:00