Category

Human STAT1 deficiencies

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 
₹ 4,396

Availability: Out of stock

 

Delivery :

Product Out of Stock Subscription

(Notify me when this product is back in stock)

  • Product Description
 

The Signal Transducer and Activator of Transcription 1 (STAT1) is activated in response to interferons (IFNs) stimulations. In response to IFN-?, STAT1 homodimerizes to form the gamma activating factor (GAF). In response to IFN-?, STAT1 heterotrimerizes with STAT2 and ISGF3-? to form the interferon sequence gene factor 3 (ISGF3). This work clearly demonstrates the distinct roles of the IFN-?-induced-GAF complexes in anti-mycobacterial immunity and of IFN-? induced- ISGF3 complexes in the anti-viral immunity in humans at the cellular and clinical levels by different molecular mechanisms. It also highlights the fact that a phenotype depends of the mutation and not only of the affected gene; and moreover the importance of the homozygosis or heterozygosis state of the mutation in human genetic diseases.

Product Specifications
SKU :COC99437
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
0 Review(s)