A good clinician should have a firm knowledge of oral pathologies, which is the science for understanding the intricate biological behavior of particular group of lesions. The approach to understanding oral disease processes will assists the clinician in the recognitions of specific conditions and in the development of differential diagnosis, rational treatment approach and prognosis. There are several excellent textbooks available on oral and maxillofacial pathology. However, the attempt has been made in this monograph to provide the basic understanding of a disease process of Combined or Hybrid Odontogenic lesions. This monograph will provide clinical & radiological details, epidemiological data, pathological findings and will focus on the question whether hybrid tumors are new entities or two subtypes composed of two exactly separate odontogenic lesions or they are solely histopathologic patterns. This is a humble attempt to find the niche for the clinicians with the current information about the hybrid Odontogenic lesions.