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Imaging of creatine deposits in human CNS tissues

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Synchrotron infrared spectromicroscopy and X-Ray Fluorescence spectromicroscopy have been applied to imagine human central nervous system tissue. Untreated, flash frozen tissue samples were analyzed at micron level spatial resolution to obtain information about chemical composition of the sample. Bright synchrotron light allowed the high spatial resolution (8-10 microns) needed for this study. In the family of neurodegenerative diseases, Amyotrophic Lateral Sclerosis (ALS) is the most frequent cause of adult onset. ALS symptoms include: generalized weakness and muscle atrophy. The motor cortex, brain stem, spinal cord and substantia nigra were mapped using infrared spectromicroscopy and the results were analysed for protein, lipids and creatine levels. Creatine is a small molecule which plays important role in metabolism. Creatine was found to be focally elevated and formed deposits located in the human ALS CNS tissue. Focally elevated creatine may be a marker of the disease process, indicative of disturbed energy metabolism or inflammatory response to the disease progression.

Product Specifications
SKU :COC16469
AuthorMarzena Zofia Kastyak
LanguageEnglish
BindingPaperback
Number of Pages132
Publishing Year2010-10-08T00:00:00.000
ISBN978-3838384832
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-25 00:00:00