Mobile Phone Technologies have the potential to improve the economic performance of MSE’s by affecting almost every structural characteristic of these organizations. With the adoption of this new technological dynamo, its usage is expected to have gained prominence by virtually all MSE’s in Kenya. This increased accessibility has introduced changes in most sectors of the economy and particularly MSEs thereby creating an impact on Kenya’s fastest growing sector and employer. Is there an impact of adoption and use of mobile phone technology among MSE’s in Kisii Town? The Research therefore was to assess the impact of adoption and use of mobile phone technology on the performance of micro and small enterprises in Kisii Town, Kenya.