The antioxidant potential of Skimmia anquetilia and Dicliptera bupleuroides methanolic extracts and fractions was evaluated using the eight multidimensional methods. The accrue data presenting that; TEAC and FRAP Value vary from 6.09-1.65mM, 7.04-2.03 for S. anquetilia and 3.5-0.4, 3.8-1.8 respectively for D. bupleuroides. Phenolic content of S. anquetilia ranged from 3.04-0.4 gallic acid (mg/L) and 1.5-0.44 gallic acid (mg/L) for D. bupleuroides. S. anquetilia and D. bupleuroides Aqueous and organic soluble fraction were rich of flavinoids which was range from 1712.7-249.1 mg catchecin eq. and 885.4-107.2 mg catchecin eq respectively. Total antioxidant activity by phosphomolybdenum method was determined for various fraction of S. anquetilia and D. bupleuroides ranged from 0.555-0.09 and 0.42-0.17 respectively. The percentage of superoxide anion radical scavenging ranged from 99.5 to 4.96 for S. anquetilia and 78.4 to 68 for D. bupleuroides. The percentage bound Iron in S. anquetilia fraction was varying from 73.5 to 61.9 and 94.8-69.2 for D. bupleuroides. The amass results of indicated that S. anquetilia and D. bupleuroides is a rich source of natural antioxidants.