The research project underscores the fact that HIV/AIDS remain the leading threat to employee and organizational performance in South Africa. The study employed triangulation hence using both qualitative and quantitative methods. The Likert survey questionnaire was used in order to evaluate the impact of implementation of an effective HIV/AIDS policy on employee and organizational performance. Furthermore, to understand the experiences of those responsible in the implementation process in depth interviews were used. The research was mainly influenced by the social development theory or the empowerment model. The research established that even though HIV/AIDS is not curable, it is manageable and preventable thus the findings were that the implementation of an effective HIV/AIDS policy has positive impacts on employee and organizational performance.