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Importance of sialic acid for infection of primary cells by IBV


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Avian infectious bronchitis virus (IBV) is the causing agent of a highly contagious disease with a major economic impact on the poultry industry. It is characterised clinically by respiratory, renal and reproductive manifestations. Despite various vaccination protocols, IBV still plays a role in poultry flocks, mostly because of the appearance of new variant strains which are not neutralized by antibodies induced by available vaccines. Viral entry into host cells is mediated by binding of the viral glycoprotein S to a receptor on the cell surface. Alpha 2,3 linked sialic acid has been reported to play an important role as a receptor determinant for IBV . Here, a comparative study of current field strains, 4/91, Italy 02 and QX has been carried out to investigate their dependence of sialic acid for infection in different primary cell culture systems. To reflect the main target organs of an IBV infection in chicken, the following tissue cultures were used in this study: a) primary chicken embryo kidney cells, b) chicken tracheal organ cell cultures (TOCs), c) chicken precision-cut lung slices (PCLS) and d) chicken oviduct explants (COE).

Product Specifications
SKU :COC33279
AuthorSahar Abd El Rahman,Christine Winter and Georg Herrler
Number of Pages96
Publishing Year2012-05-10T00:00:00.000
Edition1 st
Book TypeVeterinary medicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00
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