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In-house validation of high fat diet induced obesity models


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Obesity results from a prolonged imbalance between energy intake and energy expenditure, as depending on basal metabolic rate, heat production, thermogenic effects of the diet & physical activity. Diet-induced obesity in rodents can be achieved by different regimens & approaches. Diets providing a high fat intake have been established as a “gold standard” to generate obese rodent models and have proven to initiate pathologies similar to those in humans. However, this dietary treatment is far from being standardized and its relevance has been criticized. Hence, varieties of high fat diet regimens have been introduced by providing a choice of several palatable food items of variable composition. Further male rats have been considered in developing all types of obesity models and no rationale has been provided as of this discrimination and negligence of using female rats. Another pitfall in the obesity model development is that of the choice of the strain of the rats used for the study. The basis on which strain is being chosen still remains controversial. This present study aimed at comparing & validating different diet induced obesity models utilizing different strains and gender.

Product Specifications
SKU :COC84987
Number of Pages108
Publishing Year2013-02-03T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00