Call Us 080-41656200 (Mon-Sat: 10AM-8PM)

In-Silico Screening of Potent Anticonvulsant Agents

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 

Check Your Delivery Options

 
Rs. 3,651

Availability: In stock

 
  • Product Description
 

Epilepsy is a disorder of the central nervous system characterized by paroxysmal, excessive, hyper-synchronous discharges of large numbers of neurons. To identify novel and potent anticonvulsant ligands, initially 2D-QSAR,3D-QSAR and pharmacophore models were generated using a series some prop-2-eneamido and 1-acetyl-pyrazolin derivatives of aminobenzothiazole as anticonvulsants. To discover new hits, developed pharmacophore model was subjected to screen molecules from specs database. Screened hits which were showing good predicting activities according to both 2D and 3DQSAR models were subjected to docking screening. Gly/NMDA and AMPA receptors are effective and validated anti-convulsant targets and used to report the binding affinity of screened hit on Gly/NMDA, AMPA receptors. A representative set of 14 compounds with effective biological activity and good binding affinity on both NMDA and AMPA receptors were screen out which may potential lead for anticonvulsant activity.

Product Specifications
SKU :COC31324
AuthorKamlendra S. Bhadoriya and Nitendra Kumar Sahu
LanguageEnglish
BindingPaperback
Number of Pages76
Publishing Year5/24/2012
ISBN978-3659137266
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00
0 Review(s)