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In- Vitro and In- Vivo Interaction studies of Leflunomide


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder in which people suffer from joint as well as neurobiological disorder. These patients take multiple drugs which opens the chances of drug interaction. Therefore this book deals with the in-vitro and in-vivo interaction studies of leflunomide (a leading DMARD to treat RA) with NSAIDs, essential & trace elements. For in-vitro studies, methods were developed & validated (via ICH guide lines)on UV-spectrophotometer and HPLC which were then applied for drug interaction study. Leflunomide-metals complexes were also synthesized and characterized by IR, H1-NMR and CHN. In-vivo studies were also conducted on chronic (adjuvant induced) and acute (carrageenan induced) arthritic model. Studies highlighted that NSAIDs and metals interact significantly with leflunomideboth in-vitro & in-vivo. In order to study RA associated neurobiological disorder, effect of these drugs were also studies on rat’s brain indolamines level. These results showed that these drugs also affect brain indoleamines level in rats.

Product Specifications
SKU :COC76838
AuthorMoona Mehboob Khan
Number of Pages168
Publishing Year2014-03-20T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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