This thesis is generally concerned on validating the herbal products that Ethiopian people exploit for the remedial of cutaneous leishmanisis. Especially in remote areas many people rely on traditional medication for the treatment of a number of diseases. Most treatments they employ successfully alleviate the disease but relapse and different side effects are the most common problems encountered. Scientific investigation on those treatments especially on herbal medicines could be provide a better solution for the current problem, lack of medicine for different diseases in modern world. In the study it is found out that some of the plants were successfully destroyed the promastigote stage of L. aethiopica, the causative agent of cutaneous leishmaniasis in Ethiopia. While others did not show any activity against the parasite. It requires further investigation, like trial on the amastigote stage of leishmania, use of different parts of the plants and use of different chemical for extracting purpose, to accept and reject the therapic value of those plants.