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In Vitro stressor related changes in ovarian steroidogenesis


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  • Product Description

The study examined the affect of cortisol on basal and cAMP-stimulated in vitro steroidogenesis of rainbow trout (Oncorhynchus mykiss) ovarian follicles at different maturational stages. Basal and cAMP-stimulated 17?-estradiol (E2) and testosterone (T) production was highest during the mid-vitellogenic (MV) stage, compared with early- and late-vitellogenic stages. Cortisol suppressed the basal steroid production in the MV stage, and suppressed cAMP-stimulated steroid production in all three maturational stages. To determine whether cortisol exerts its effect on pregnenolone (P5) production, real time RT-PCR was used to measure the expression of genes coding for steroidogenic acute regulatory (StAR) protein, and cytochrome P450scc. There was no significant affect of cortisol on the expression of either gene. To look for possible actions of cortisol on steroidogenic enzyme function, the effect of the glucocorticoid on the biotransformation of radiolabelled P5, and T was examined; cortisol appeared to suppress the aromatization of androgens to estrogens by a mechanism that is not fully understood.

Product Specifications
SKU :COC97585
AuthorSangjucta Barkataki
Number of Pages164
Publishing Year2011-05-18T00:00:00.000
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandNot defined
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-18 00:00:00