In the process of pursuing the objective of vaginal drug delivery system, Our work was aimed on in-vitro-in-vivo correlation of Zidovudine loaded particulated vaginal bioadhesive tablet.The graphical analysis confirms, a good degree of correlation. Fulfilling our objective. A good correlation was observed between the release rate constant and AUC of the formulation also between the mean dissolution time and mean residence time of the designed formulation epitomized. Degree A level of correlation was established from the results. Thus, the formulation has the potential to liberate Zidovudine following Fickian diffusion mechanism having a good degree of in-vitro- in-vivo correlation.