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Increasing the immuno-stimulatory capacity of human leukemia cells


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The ultimate goal of tumor immunotherapy is the eradication of tumor cells by the immune system. Immunotherapy for leukemia is a promising targeted strategy to prevent relapse and to prolong the survival of leukemia patients by eliminating residual leukemic cells that survive standard therapy. However, in order to elicit effective immune responses during immunotherapy, the immune tolerance against leukemic cells needs to be broken. Mechanisms that contribute to immune tolerance are the lack of expression of costimulatory molecules by leukemic cells and the lack of danger signals in leukemic cells and/or in their microenvironment. Here, we studied the ability of RNA molecules or synthetic derivatives to increase the immunogenicity of acute myeloid leukemia (AML) cells and to break the non-responsiveness of immune cells to AML cells, in the light of their potential future use in leukemia immunotherapy strategies.

Product Specifications
SKU :COC94704
AuthorEvelien Smits,Peter Ponsaerts and Viggo Van Tendeloo
Number of Pages232
Publishing Year2011-09-22T00:00:00.000
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00