Metabolic Syndrome is an aggregation of conditions that together increases the risk of cardiovascular disease in individuals that would not otherwise be recognized to be at risk. Aim: to assess the status of high sensitive C reactive protein (hs-CRP) in patients with Metabolic Syndrome. METHODS: This study is a cross-sectional study. The patients included in this study were 48 patients (of both sexes) attending the Diabetic Consultant Clinic during the period from January, 2010 till the end of September, 2010. The study included another 50 apparently healthy volunteer that were comparable to patients group with respect to age and sex and serve as a control group. They were screened for Metabolic Syndrome criteria.For the two groups hs-CRP was measured using ELISA kit. The results: BMI and BP were significantly higher in the MetS than the control. MetS group had significantly higher (hs-CRP) levels than control group and significantly higher Lipid profile than the control group. In conclusion, high sensitive C Reactive Protein can thus be simple, powerful markers of Metabolic Syndrome.