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Inhibition Of Cell Proliferation Through R.i.p. Of Creb3l1


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

“Inhibition of Cell Proliferation through Regulated Intramembrane Proteolysis of CREB3L1” guides the reader though the discovery of CREB3L1 as a membrane-bound transcription factor that prevents the proliferation of virus-infected cells. Upon activation, CREB3L1 is found to block the proliferation of cells infected with diverse DNA and RNA viruses, including murine gamma-herpesvirus 68, HCV, West Nile virus, and Sendai virus. The reader is then lead through the discovery that doxorubicin, a widely used anti-cancer drug, requires CREB3L1 to perform the anti-proliferative function utilized in cancer therapy. Data is presented that doxorubicin stimulates de novo synthesis of ceramide, which in turn activates the regulated intramembrane proteolysis of CREB3L1. This leads to the transcription of anti-proliferative genes that block tumor cell proliferation.

Product Specifications
SKU :COC30203
AuthorBray Denard
Number of Pages112
Publishing Year2012-04-09T00:00:00.000
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00