Fluid therapy in veterinary patients is an emerging area having tremendous potentialities. Plasma transfusion is a life saving application in the therapeutic and prophylactic management of conditioned encountered in veterinary practice. Calves suffering from malnutrition, parasitism and anemia may not respond to conventional treatment. Plasma transfusion in these animals might be practiced to promote body immunity and thereby to reduce mortality as plasma transfusion is free from the risk of incompatible reaction. Calves in the rural areas reared under poor husbandry practices suffer from anemia, malnutrition, mineral and electrolyte deficiency. These calves do not respond to specific transfusion. That’s why we have initiated to study the influence of plasma and vitamins and minerals on the improvement of health status of calves in the field condition.