The modern global economy presents difficult challenges to small enterprises. The larger organisations are growing on a global scale affecting, with their investments, the smaller companies. The high level of competition coming from the internationalisation and globalisation processes speeds up the investment flow towards the foreign markets. The business dynamics change suddenly requiring companies to deep scan the market. It is the ability, the long-life innovation and learning, the attitude to risk and investment that are able to solve the dilemma between business occasion and growing risk. Small companies have a great possibility to be the next first player on the global scene, but only through alliances will they be able to achieve the best occasions, minimising the possibilities to fail. This book analyses the way Italy and Wales are trying to fill the gap left, through the use of their best instruments. It also tries to understand how the great challenges of the global economy can be met so as to enhance the small business as a first player for the local economy.