The present study offers an investigation into the notion of interstitial space and its creative exploration in architecture and site-specific art, realized through digital technology. Based on cosmology, Quantum Physics and information theory, instead of being perceived as a ?ground zero?, space is evolving and heterogeneous as it comprises of multiple interacting layers of virtuality and reality. Contemporary site-specific art is marked by a growing interest in exploring emerging interstitial spaces including transitional and unsettling in-between spaces, the emergence of which, deeply challenges spatial and disciplinary boundaries. Such an investigation includes a creative exploration of the possible inter-relationships between various types of reality and the dynamic and unsettling points of intersection enabling various kinds of exchange between those realities. The emphasis is placed on the ways in which, potential interstitial spaces can be creatively revealed through various modes of innovative spatial intervention such as mixed realities, parallel sites, inter-spaces, infra-spaces.