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Isolation of Cobra Venom Cytotoxin FVIb

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

The search for cancer cure from natural products have been practiced for over a century. For the last 25 years, El-Asmer and co-workers were pursuing the search for potential therapeutic agent or new drug models from snake venoms. This work was presented for partial fulfillment of M.D. in Biochemistry. A cytolytic, non-antigenic, 8 kDa, glycoprotein (Fraction VIb) was isolated from crude Naja nigricollis nigricollis spitting cobra venom. This protein is stable at different pH values and different temperatures up to 100ºC, lethal to mice, with LD50 1.83 mg/kg. Small doses induced cytolytic effect on hepatocellular carcinoma, colon cancer and breast cancer cells while larger doses caused hemolysis of red blood cells. Thus, this protein can be considered a target compound for further researches as it can be a potential bio-therapeutic agent for cancer treatment, or a model for new drug design.

Product Specifications
SKU :COC36257
AuthorDalia Ali Gaber,Mohamed Farid El-Asmer and Kamelia Ahmed Zaki
LanguageEnglish
BindingPaperback
Number of Pages148
Publishing Year2012-10-02T00:00:00.000
ISBN978-3846582114
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00