This study examined sources of job stress among secondary school teachers of Buea Sub-Division, and the strategies they use to cope with stressful situations. The researcher presupposed that student indiscipline, salary levels, under-promotion, work overload and teacher-principal interaction could be possible job stressors of secondary school teachers. The second preoccupation was to discover coping strategies of secondary school teachers in the management of job stress. A sample of 200 secondary school teachers in Buea Sub-Division was used for this study. A questionnaire was the instrument for data collection, while the statistical analysis of data was done using the chi-square test. The results revealed the following: It is very likely that teachers lose enthusiasm for their work when they have a sense of under-promotion. Two confounding factors, that is, individual personal differences and social support systems moderate the impact of stressors on teachers, influence their appraisal of socio-environmental demands as stressful, and determine the effectiveness and ineffectiveness of the coping strategies generated to manage job stress.