In the area of bioinorganic chemistry, transition metal complexes of Schiff bases have attracted a lot of interest due to their potent biological activities such as: ? Anti-bacterial active. ? Anti-fungal active. ? Anti-cancer active. ? Antioxidant active. ? Antimalarial active. ? Antiviral active. ? Anti-in?ammatory active. It was reported that complexation of metals to Schiff base ligands improves the antimicrobial and anticancer activities of the ligands. Some research groups found that the Schiff base metal complexes derived from salicylaldehyde can specially cleave the DNA. Also, Schiff bases used in the following: ? As gravimetric reagent. ? For removal of uranium (VI) from aqueous solutions. ? As urease inhibitor. ? As corrosion inhibitor. Iron Schiff base complexes provide useful structural and electronic models for the similarly coordinated sites found in the heme iron enzymes and their structure and catalytic activity are analogous with those of iron porphyrins. Studying the interaction between transition metal complexes and DNA has attracted many interests due to their importance in cancer therapy, design of new types of pharmaceutical molecules and molecular biology.