GICs widely used in dentistry due to its unique properties in the field of restorative dentistry. GIC was introduced in 1960’s due to clinical importance,goes through non-stop upgrading, development and modification.Release of therapeutic ions like fluoride, calcium and strontium which aids in mineralization of tooth structure.Sr and F possess anticariogenic property.Sr improves the radio-opacity of the GICs. Therefore this book explains release of different ion from GICs at acidic medium and role of Sr in improving radio-opacity of the cement. GICs are component of minimal invasive dentistry due to their unique properties including release of ions,chemical adhesion to tooth structure, inhibition of bacterial growth and secondary caries formation around restoration resulting in providing aid in both external and internal remineralization. The release of F and Sr in acidic medium can prevent demineralization and enhance remineralization by diffusion mechanisms. Buffering action of GICs can prevent the decrease of pH and prevent dissolution of tooth structure. Sr in GICs improves the radio opacity.Researches and dental professionals can utilize the knowledge from this book.