This descriptive study was designed to examine the knowledge, attitude, beliefs, and perception toward PLWHA. Among selected medical personnel in State Hospital Two – Hundred randomly selected respondents were Nurse, Doctors pharmacists, Laboratory scientist, social workers. Six hypotheses were formulated and tested using Anova and T-Test. The study shows that the medical personnels have adequate knowledge and positive attitude toward the care of PLWHA. Nevertheless, the study reviewed a slight negative attitude on the part of student nurses. Some percentages of the student were homophobia on the diagnosis of this aliment. Suggestions where made on medical managers to provide enough resources, motivation and encourage all sectors of medical personnels so that they can achieve their aims in the nearest future. Suggestions were made for professional counselors to involve themselves in counseling service in State Hospitals. All values at o.oo level of significant.