Knowledge management scalars over the past decades have developed a verity of techniques that tackle the problem of organizing and managing data, information and knowledge in our society. These techniques were used to manage knowledge on papers and intellectual knowledge as well some digital and binary ones. This research is aimed at evaluating existing Measure of Semantic Relatedness functions. The area that this study is intended for is Multimedia and its corresponding sub-domains. This research takes an analytical approach toward figuring out the level of efficiency for MSR functions if they are to be applied in the domain of multimedia. More than 100 papers and articles on various sub-domains of multimedia were analyzed in order to identify a batch of words for each sub-domain which are most frequent and therefore more likely to be related to the domain of interest. Two set of back to back survey questionnaires were distributed among 89 lecturers of multimedia university. The results of the surveys were further analyzed to figure out the nature if relationship between the relatedness scores generated by MSR functions and those created by human opinion.