This study explores the contributions of endogenous knowledge resources to local economic development in Uganda. Using a cross-sectional descriptive design and a triangulation approach of qualitative and quantitative approaches, the study found out that the sectors where endogenous knowledge resources are applied, range from; agriculture, technology, traditional medicine, environment, and local governance. The contributions of local knowledge resources to local economic development include; improvement of local economic growth,human development, improved community health, environmental conservation and agriculture. In order to harness endogenous knowledge, The contributions of local knowledge resources to local economic development include; improvement of local economic growth; improved human development; improved community health; environmental conservation and agricultural development. The overall study came up with recommendations to; strengthen endogenous development planning, strategise language development, revamping the prevailing land use attitudes, and the promotion of knowledge and learning economies.