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L-carnitine and CoQ10 role in combating deteriorative effect of CCL4


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  • Product Description

Liver cirrhosis is one of the most dangerous health problems which result from various disorders that damage liver cells over time. The purpose of this work is to evaluate the prophylactic effect of L-carnitine, coenzyme Q10 (CoQ10) or their combination against the deteriorative effect induced by carbon tetrachloride (CCl4) on rat's liver. Administration of CCl4 provides a suitable animal model for free radical damage in liver such as fatty degeneration, fibrosis, hepatocellular death and carcinogenicity. The study was carried out on rats as follows: four normal groups (control, treated with L-carnitine, treated with CoQ10, and treated with combination of L-carnitine and CoQ10) and four cirrhotic groups treated with CCl4 (control, treated with L-carnitine, treated with CoQ10, and treated with combination of L-carnitine and CoQ10). Effect of L-carnitine and CoQ10 as protective agents against liver cirrhosis was determined by measuring hepatic content of reduced glutathione, lipid peroxides, ascorbic acid, total protein and lactate dehydrogenase. Also, serum activities of alanine aminotransferase, aspartate aminotransferase, total protein, albumin, sialic acid, nitrite and lactat

Product Specifications
SKU :COC36182
AuthorSanaa Ahmed Ali,Lilla M. Faddah and Asmaa Bayoumi
Number of Pages260
Publishing Year2012-07-07T00:00:00.000
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00
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