Landslide is a common natural hazard that usually occurs in mountainous high land areas of Ethiopia. Landslide risk assessment is important to take quick and safe mitigation measures and make strategic planning for the future. The objective of this research was conducting a landslide risk assessment with GIS and remote sensing at scale (1:50,000). The model is applied for the Hagere Selam province of Tigray Regional State, Northern part of Ethiopia, covering approximately 490km2. Three conditions have been considering for landslide risk assessment: completely dry condition, half saturated condition and fully saturated condition. The result of the analysis has been found that 0.54% of the area unstable, 2.31% of the area quasi stable, 4.33% of the area moderately stable and 92.82% of the area stable for completely dry condition. For the half saturated condition: 4.59% of the area unstable, 4.94% of the area quasi stable, 5.56% of the area moderately stable and 84.90% of the area stable. And for the fully saturated condition: 25.49% of the area unstable, 5.95% of the area quasi stable, and 5.11% of the area moderately stable and 63.45% of the area stable.