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Liver damage by interaction of malathion with cimetidine

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

The results show support for concern about extrapolating data to humans, given the degree and forms of exposure to these kind of compounds. In this study the authors aimed to evaluate the oxidative stress enzymes indicative of liver damage in rats exposed to M (malathion) acute and chronic forms using C (cimetidine) and cimetidine plus malathion (M + C). Malathion, widely used organophosphorus insecticide worldwide, induces oxidative liver damage type; Cimetidine is an antagonist of histamine H2-receptor, it has been shown to be an inhibitor of various CYP450 isoforms. Male Wistar rats weighing 200-250 g were studied, exposed to malathion orally for 3 weeks (0.15 mg/kg/day, 2 mg/kg/day, 15 mg/kg/day) and cimetidine 10 mg/kg/day. Malathion affects susceptibility to oxidative stress and possibly modifies the antioxidant defense capacity directly or indirectly.

Product Specifications
SKU :COC76585
AuthorAlba Delia Campaña Salcido and Anthon Alvarez Arredondo
LanguageEnglish
BindingPaperback
Number of Pages68
Publishing Year2014-08-15T00:00:00.000
ISBN9783659560392
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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