A geographic concentration of HIV/AIDS epidemic in Nepal. The immediate and vigorous action must be taken to prevent further spread of HIV among the high-risk groups and stop the infection from taking a foothold in the larger most at risk population. The HIV epidemic continues to be characterized by high prevalence among various sub-groups whose sexual or drug use behaviors places them at risk of HIV. IDUs, FSWs and their clients, MSM and returnee migrants have higher prevalence levels than the general population. The key interventions in risk groups were directed towards prevention of transmission, reduction of risk factors/behavior and focus on promotion of safe sexual behavior through health education, care and support, and rehabilitation.