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Mass Spectrometry Studies of DNA-Directed Alkylating Agents


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  • Product Description

This work is focused on the use of Mass Spectrometry based technique to determine the site of drug binding and to observe the chemical reactions that occur during ligand-DNA interaction. Such approach is useful and has great potential in aiding DNA targeted drug design in terms of assessing the ligand DNA cross-linking ability, sequence specificity and to certain extent, degree of reactivity for a particular binding site. This work is part of a wider effort in developing drugs that target the minor groove region of the DNA which has been known to be invisible to DNA repair enzymes, a common problem that leads to cancer drug resistance. Mass spectrometry has many advantages in comparison to the conventional techniques applied in DNA targeted drug design. It can provide detail insights into the chemistry of drug-DNA interactions at high level of accuracy and sensitivity.

Product Specifications
SKU :COC48552
AuthorAmin Malik Shah Abdul Majid
Number of Pages584
Publishing Year2010-09-13T00:00:00.000
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-04-08 00:00:00
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