One adult in ten will have Diabetes by 2030. Number of people living with diabetes was 366 million in 2011 which is expected to rise to 522 million by 2030. This equates to roughly three new cases every ten seconds or almost ten million per year. Between 2010 and 2030, there will be a 69% increase in number of adults with diabetes in developing countries and a 20% increase in developed countries. Diabetes mellitus is considered to be one of a rank of free radical diseases which propagates complications with increased free radical formation. Diabetic nephropathy (a micro-vascular complication) is the most common cause of end stage renal disease (ESRD). If untreated, 80% of people who have type-1 diabetes and microalbuminuria will progress to overt nephropathy whereas 20-40% of those with type-2 diabetes over a period of 15 years will progress. It is concluded that diabetic patients suffer more from oxidative stress. Oxidative stress is still higher in diabetic patients with nephropathy complication than patients without nephropathy.