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Mesenchymal Stem Cells Therapy in Cisplatin-Induced Nephrotoxicity


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Stem cell therapy has the future to change the face of human diseases and alleviate suffering. Mesenchymal stem cells (MSCs) have generated a great deal of excitement and promise as a potential source for stem cell-based therapeutic strategies. These data provide the clue of using MSCs in the current work to modulate cisplatin-induced nephrotoxicity, the severest adverse effect of the well-known anticancer drug; cisplatin. Forty adult albino rats were used in this study; MSCs of bone marrow origin were injected into the rat tail vein one day after a single dose of intra-peritoneal injection of cisplatin. Four weeks later, the kidney was examined morphologically, histopathologically and ultra-structurally. Renal functions (urea, creatinine) as well as serum electrolytes levels (Na, K) were estimated. Cisplatin produced marked histopathological changes in rat kidney and impaired renal functions however; MSCs ameliorated cisplatin-induced nephrotoxicity both functionally and structurally to a great extent. MSCs have a potential therapeutic effect against cisplatin-induced nephrotoxicity.

Product Specifications
SKU :COC84762
AuthorHanan Dawood Yassa,Safwat Wadie Gergis and Hassan Abdel Raheem
Number of Pages64
Publishing Year2013-11-25T00:00:00.000
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00