Besides infectious diseases result in innumerable deaths world over, microbial resistance to antimicrobials put additional pressure of increased illness severity, duration, mortality and health costs including costs on prevention and control measures and development of alternate drugs. It makes advances in therapy ineffective, more complicated and more expensive based on scope of problem. Hence, there is an urgency to find out ways to address the issue of microbial resistance. To meet the challenges of microbial resistance to antimicrobials, we must improve our understanding of microbial world, evolution of their resistances, mechanism of transmissibility of resistant organisms, quality of research, surveillance and survey to find out remedies to prevent, eliminate and control the resistance. This particular book tried to put flash light on all these topics in depth.