Call Us 080-41656200 (Mon-Sat: 10AM-8PM)
Free Shipping above Rs. 1499
Cash On Delivery*

Mitochondrial Dynamics and Uncoupling Protein 2 In The Hippocampus

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 

Check Your Delivery Options

 
Rs. 3,718

Availability: In stock

 
  • Product Description
 

Mitochondria are a crucial site of energy metabolism in neurons. The energy demand is higher in neurons than in most other cells, which is reflected by high consumption of oxygen in the brain. In neurodegenerative pathology, reactive oxygen species (ROS) may lead to oxidative stress and mitochondrial DNA (mtDNA) damage. The transgenic mutated uracil-DNA glycosylase 1 (mutUNG1) mice express the mutUNG1 enzyme, which induces mitochondrial toxicity, caused by high numbers of apurinic/apyrimidinic-sites in mtDNA of hippocampal neurons. The uncoupling protein 2 (Ucp2) has the ability to protect neurons against a critically high mitochondrial membrane potential, thereby reducing ROS production. This book has been articulated with recent findings of mitochondrial dynamics and localization of increased level of Ucp2 in different compartments of hippocampal pyramidal neurons in a mouse model of mitochondrial DNA toxicity. The significantly increased density of Ucp2 has been investigated in the somas of pyramidal neurons which could result from the large numbers of damaged mitochondria transported to the somas from different compartments of the neurons in the mutUNG1-expressing mice.

Product Specifications
SKU :COC56098
AuthorMd. Mahdi Hasan,Knut Husø Lauritzen and Linda Hildegard Bergersen
LanguageEnglish
BindingPaperback
Number of Pages88
Publishing Year2014-06-24T00:00:00.000
ISBN9783659387852
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-06-08 00:00:00