Designing a complete Distribution Network requires critical analysis of both Qualitative and Quantitative factors. Quantitative factors constitute impact on cost of distribution network while qualitative factors have impact on the service level issues. Since, this book deals with a practical industrial problem. Therefore I have taken up a case of Pakistan Tobacco Company, a Subsidiary of British American Tobacco, a Multinational Operating in Pakistan since its birth. It is a FMCG company manufacturing tobacco products in Pakistan. This book studies the impact of different factors on designing of distribution network and then formulates the mathematical model for determines transportation schedule, number of distribution channels in a Distribution Network. In this study, we focused on the minimizing the total distribution network cost by adopting the techniques of Mathematical programming and challenging distribution cost.