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Modelling Biomolecules

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

This work addresses the basic problems of biology and medicinal chemistry. The main focus is to understand structural features and mechanism of therapeutically relevant targets viz. H+K+?ATPase, Ca2+?ATPase and DNA with the aid of CADD tools. This includes the comparative study of proteins, their structural differences and the role of pKa of titratable residues in the active site, probing the structural requirement of ligands in order to develop strategies to design new inhibitors and/or to modify known ligands to augment the activity. I analyzed the aromatic networks in membrane proteins to understand the important role played by aromatic residues in transporting cations across the membrane. This study has been extended at database level considering all proteins of Protein Data Bank to find out specific patterns of aromatic?aromatic networks and their connectivity in proteins. There has been a profound interest in designing the covalent and non?covalent DNA minor groove binders which interact with the DNA in sequence-selective fashion. The rigorous benchmarking study to design new leads for DNA minor groove binders has also been mentioned in this book.

Product Specifications
SKU :COC39971
AuthorMukesh Chourasia
LanguageEnglish
BindingPaperback
Number of Pages240
Publishing Year2/28/2012
ISBN978-3848401758
Edition1 st
Book TypeChemistry
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-02-08 00:00:00