Proliferation of new businesses in this century will continue to be a permanent feature as one of the building blocks of economic growth for national and world economies. Resource commitments to a new business are hefty and few business investments have been observed to achieve good returns on investment. Many of the new business investments become risky; creating wastage of scarce resources invested and culminating in leaving the wonderful dreams of many upcoming entrepreneurs completely shattered. The large numbers of failed businesses cause untold sufferings to the entrepreneurs, their friends and families; leave alone the inability to produce positive economic contribution to national and world economies. This Modern Business Handbook; Building Blocks for Successful Entrepreneurs, is themed around the art of carrying out new business operations and management practices towards a modern economy in this century. It is an accurate collection of a wide vertical and horizontal business experiences and consultation packaged into sixteen chapters. This Modern Business Handbook is therefore, a valuable companion for professionals and students pursuing a rewarding career in business.