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Modulation of actin dynamics by the S.pneumoniae toxin pneumolysin

 

Marketed By :  Südwestdeutscher Verlag für Hochschulschriften   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 
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  • Product Description
 

The pneumococcus is one major cause of bacterial meningitis, a wide-spread disease of newborn and immune-compromised individuals, which shows CFRs up to 50% in countries with low medical standards. Bacterial spreading affects the meninges, and the sub-meningeal cortex tissue, whereat the presence of pneumolysin, a major virulence factor of the pneumococcus, is prerequisite for the development of a severe outcome of the infection and associated tissue damage. Pneumolysin belongs to the family of cholesterol-dependent cytolysins, which use membrane-cholesterol as receptor and oligomerize to big aggregates, which induce cell lysis and cell death by disturbance of membrane integrity. This work has revealed a new picture of pneumolysin, whose cell-related properties go beyond pore formation and cell lysis. A direct interaction of the toxin with actin leads to cell-shape remodeling in astrocytes, which potentially disturbes neuronal homeostasis and favors bacterial tissue penetration.

Product Specifications
SKU :COC36461
Country of ManufactureIndia
Product BrandSüdwestdeutscher Verlag für Hochschulschriften
Product Packaging InfoBox
In The Box1 Piece
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