Breast cancer is known as one of the most common causes of death among women worldwide. It is an aggressive type of cancer since it may invade other tissues in different ways. Breast cancer has been one of the major interests for research studies, especially in terms of gene profiling. Her-2/neu is a main gene to be studied in order to understand the status of the disease. Here in this book, Her-2/neu was evaluated using three different techniques; which revealed interesting results.